- AF Bank (Ashe Federal): West Jefferson, Jefferson, Warrensville, Boone
- Alliance Bank & Trust: Gastonia, Shelby
- American Community Bank: Monroe, Charlotte, Indian Trail, Marshville + locations in South Carolina
- Anson Bank & Trust: Wadesboro
- Asheville Savings Bank: Asheville, Black Mountain, Mars Hill, Marion, Hendersonville, Brevard, Candler
- BB&T Banking: Bank subsidiaries operate more than 1,400 branch offices in the Carolinas, Virginia, West Virginia, Kentucky, Georgia, Maryland, Tennessee, Florida, Alabama, Indiana, and Washington, D.C.
- Bank of America: Several Locations Nationwide.
- Bank of Currituck: Moyock, Camden, Grandy, Corolla, Kill Devil Hills, Southern Shores
- Bank of Granite: Locations in Catawba County, Caldwell County, Burke County, Mecklenburg County, Watauga County, Wilkes County, Forsyth County
- Bank of North Carolina: Thomasville, Archdale, Lexington, High Point, Kernersville, Oak Ridge, Salisbury, Harrisburg
- Bank of Oak Ridge: Oak Ridge, Summerfield, Greensboro
- Bank of Stanly: Albemarle, NC
- Bank of the Ozarks: North Carolina Locations; Charlotte
- Bank of Union: Union City, El Reno
- Bank of Wilmington: Wilmington, Hampstead, Surf City, Leland
- Blue Ridge Savings Bank: Asheville, Boone, Brevard, Fletcher, Hendersonville, Maggie Valley, Stanley, West Asheville
- Cabarrus Bank & Trust: Concord, NC
- Capital Bank: Asheville, Burlington, Cary, Graham, Greensboro, Hickory, Mebane, Morrisville, Oxford, Pittsboro, Raleigh, Sanford, Siler City, Wake Forest
- Cardinal State Bank: Durham, NC
- Carolina Bank: Greensboro, Asheboro
- Carolina First Bank: Locations in North and South Carolina
- Citizens South Bank: Gastonia, Mount Holly, Dallas, Stanley, Salisbury, Rockwell, Mooresville, Cornelius, Monroe, Stallings, Weddington, Belmont
- Coastal Federal Savings Bank: Boling Spring Lakes, Oak Island, Shallotte, Southport, Sunset Beach, Loris, Wilmington, + locations in SC
- Colonial Savings, F.A.: Charlotte North Carolina
- Cooperative Bank: Beaufort, Belhaven, Elizabethtown, Jacksonville, Kill Devil Hills, Morehead City (Business Banking), Morehead City, Southport, Tabor City, Wallace, Washington, Wilmington, Whiteville
- Cornerstone Bank: Wilson, ND
- Crescent State Bank: Apex, Cary, Clayton, Garner, Holly Springs, Pinehurst, Raleigh, Sanford, Southern Pines
- East Carolina Bank (ECB): Currituck, Avon, Hatteras, Manteo, Nags Head, Ocracoke, Kitty Hawk, Engelhard, Fairfield, Swan Quarter, Columbia, Creswell, Hertford, Williamston, Washington, Greenville, New Bern, Morehead City, Wilmington
- F&M Bank (Farmers & Merchants Bank): Granite Quarry, Faith, China Grove, Rockwell, Salisbury, Kannapolis, Concord,
- First Bank: (First BanCorp) Serving North Carolina, South Carolina and Virginia Communities
- First Carolina State bank: Rocky Mount, Tarboro
- First Charter: Charlotte, Concord, Cornelius, Denver, Indian Trail, Lincolnton, Maiden, Matthews, Mint Hill, Monroe, Mooresville, Raleigh, Cary, Garner
- First Citizens Bank: North Carolina, Virginia, West Virginia, Tennessee and Maryland
- First Federal: Sunset Beach (NC)+ locations in SC
- First National Bank and Trust: Burlington, Graham, Siler City, Greensboro, Biscoe, Pinehurst, Southern Pines, Hillsborough, Archdale, Asheboro, Ramseur, Randleman, Seagrove, Trinity, Ellerbe, Rockingham, China Grove, Kannapolis, Salisbury, Laurinburg
- First National Bank of Shelby: Bessemer City, Boiling Springs, Cramerton, Forest City, Gastonia, Kings Mountain, Lawndale, Rutherfordton, Shelby
- First South Bank: Buxton, Chocowinity, Durham, Elizabeth City, Fayetteville, Greenville, Hope Mills, Kill Devil Hills, Kinston, Lumberton, New Bern, Raleigh, Rocky Mount, Tarboro, Washington
- First Trust Bank: Charlotte, Mooresville, Concord, Monroe
- First Citizens Bank: Locations in the following states; Maryland, North Carolina, Tennessee, Virginia, and West Virginia
- FNB Southeast: NC; Greensboro, Burgaw, Eden, Madison, Reidsville, Ruffin, Wilmington + locations in VA
- Fort Sill National Bank (FSNB): NC: Fayetteville, Hope Mills, Hacksonville, Marine Corps Air Station-New River (MCASNR), Mebane, Raleigh, Rockingham, Spring Lake, Wake Forest, Wilmington
- Four Oaks Bank & Trust Company: Four Oaks, Clayton, Smithfield, Garner, Benson, Fuquay-Varina, Wallace, Holly Springs, Harrells, Zebulon
- Gateway Bank: Edenton, Elizabeth City, Kitty Hawk, Moyock, Nags Head, Plymouth, Raleigh, Roper + locations in VA
- High Country Bank: 22 locations in the Yadkin Valley, High Country and Piedmont Regions. Linville, Boone, W. Jefferson, Jefferson, Elkin, Jonesville, N. Wilkesboro, Wilkesboro, N. Elkin, East Bend, Yadkinville, Statesville, Mooresville, Cornelius, Huntersville
- High Point Bank: High Point, Jamestown
- Highlands Union Bank: Boone, Banner Elk + locations in Tennessee and Virginia
- Home Savings Bank: Eden, NC
- Home Trust Bank: Asheville, Clyde, Hendersonville, Waynesville, Weaverville
- Lexington State Bank (LSB) The Bank: Lexington, North Carolina
- Macon Bank: Arden, Brevard, Cashiers, Highlands, Franklin, Hendersonville, Murphy, Sylva
- Mechanics and Farmers Bank (M&F): Charlotte, Durham, Raleigh, Winston-Salem
- Mercantile Bank: Headquartered in Greenville, South Carolina, The South Financial Group is a multi-bank holding company with assets totaling approximately $14 billion. With approximately 172 branches in South Carolina, North Carolina, and Florida.
- Mid Carolina Bank: Burlington and Graham
- Millennia Community Bank: Greenville, NC
- New Century Bank: Dunn, Lillington, Clinton, Goldsboro
- New Century Bank South: Fayetteville, Dublin, Lumberton, Raeford, Pembroke
- Nexity Bank: Correspondent banking offices in Winston Salem, North Carolina *
- North State Bank: Raleigh, Garner, Wilmington
- Paragon Commercial Bank: Raleigh, Durham, Cary
- Piedmont Bank: 22 locations in the Yadkin Valley, High Country and Piedmont Regions. Linville, Boone, W. Jefferson, Jefferson, Elkin, Jonesville, N. Wilkesboro, Wilkesboro, N. Elkin, East Bend, Yadkinville, Statesville, Mooresville, Cornelius, Huntersville
- Piedmont Federal: Boone, Kernersville, North Wilkesboro, Clemmons, Winston-Salem
- Randolph Bank: Asheboro, Burlington, Mebane, Randleman
- RBC Centura: Locations in the following States; Delaware, Florida, Georgia, Kentucky, Maryland, North Carolina, South Carolina, Tennessee, Virginia, West Virginia, Washington D.C.
- Regions Bank: Locations in Alabama, Arkansas, Florida, Georgia, Illinois, Indiana, Iowa, Kentucky, Louisiana, Mississippi, Missouri, North Carolina, South Carolina, Tennessee, Texas, Virginia
- Roanoke Rapids Savings Bank: Roanoke Rapids, North Carolina
- Security Savings Bank: Southport, Shallotte, Leland, Calabash, Oak Island, Sunset Beach, Liberty, Randleman, Whiteville
- Shelby Savings Bank: Shelby, NC
- Silicon Valley Bank: North Carolina Locations: Chapel Hill, NC
- Sound Bank: Cape Carteret, Morehead City
- Southern Bank: Mount Olive, N.C
- Southern Community Bank and Trust (SCBaT): Clemmons, Dobson, Greensboro, High Point, Jonesville, Kernersville, King, Madison, Mooresville, Mount Airy, Pilot Mountain, Sandy Ridge, Union Grove, Walnut Cove, Winston-Salem, Yadkinville
- SterlingSouth Bank: Greensboro
- Taylorsville Savings Bank, SSB: Hickory, Hiddenite, Taylorsville
- The Bank of Currituck: Moyock, Camden, Grandy, Corolla, Kill Devil Hills, Southern Shores
- The Bankers Bank: Charlotte, NC (Winston-Salem = Business Development Office) + locations in other states.
- The East Carolina Bank (ECB): Currituck, Avon, Hatteras, Manteo, Nags Head, Ocracoke, Kitty Hawk, Engelhard, Fairfield, Swan Quarter, Columbia, Creswell, Hertford, Williamston, Washington, Greenville, New Bern, Morehead City, Wilmington
- The Heritage Bank: Bailey, Fremont, Kenly, Lucama, Middlesex, Pikeville, Pine Level, Pinetops, Goldsboro, Sims, Smithfield, Tarboro, Wilson
- The Little Bank: Kinston, Goldsboro, LaGrange, Jacksonville, Greenville
- The Scottish Bank: Charlotte, NC
- Tryon Federal Bank: Tryon, Columbus
- United Community Bank: Locations in Georgia, North Carolina, and Tennessee
- U.S. Trust Company: Locations in the following states; California, Connecticut, Delaware, Florida, Massachusetts, Minnesota, New Jersey, New York, North Carolina, Oregon, Pennsylvania, Texas, Washington, Washington, DC
- Waccamaw Bank: Whiteville, Tabor City, Chadbourn, Wilmington, Shallotte, Supply, Southport, Elizabethtown, Heath Springs
- Wachovia: Several Locations
- Woodforest National Bank: locations in TX, NC, and Virginia
- Yadkin Valley Bank: 22 locations in the Yadkin Valley, High Country and Piedmont Regions. Linville, Boone, W. Jefferson, Jefferson, Elkin, Jonesville, N. Wilkesboro, Wilkesboro, N. Elkin, East Bend, Yadkinville, Statesville, Mooresville, Cornelius, Huntersville
